Piperidines Synthesis Essay

Asymmetric synthesis of substituted NH-piperidines from chiral amines

Lekh Nath Gautam,a  Yijin Su,a  Novruz G. Akhmedov,a  Jeffrey L. Petersena  and  Xiaodong Shi*a 

Abstract

Previously, we reported an efficient asymmetric synthesis of substituted piperidines through an exocyclic chirality induced nitroalkene/amine/enone (NAE) condensation reaction. An effective protecting group strategy was developed herein to achieve enantiopure piperidines (yields up to 92%) with complete chirality retention (ee > 95%). A simple derivatization of the obtained piperidines gave thiourea catalysts, indicating the strong potential of this method for producing new amine-based dual functional organocatalysts for future development.

MDPI and ACS Style

Zhao, H.; Zhao, W.-B.; Zhu, J.-S.; Jia, Y.-M.; Yu, C.-Y. An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars. Molecules2013, 18, 6021-6034.

AMA Style

Zhao H, Zhao W-B, Zhu J-S, Jia Y-M, Yu C-Y. An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars. Molecules. 2013; 18(5):6021-6034.

Chicago/Turabian Style

Zhao, Hui; Zhao, Wen-Bo; Zhu, Jian-She; Jia, Yue-Mei; Yu, Chu-Yi. 2013. "An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars." Molecules 18, no. 5: 6021-6034.

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