The Stem Cell Debates
Lessons for Science and Politics
The Witherspoon Council
In December 1994, a committee that advises the director of the National Institutes of Health met on the NIH campus in Bethesda, Maryland. The meeting focused on the recent recommendation of the NIH’s Human Embryo Research Panel that the federal government should fund a range of research involving human embryos.
The chairman of the panel told the committee about the “extremely high level of public ignorance” about human reproduction, which “invites exploitation by those who, for moral reasons, object to human embryo research.” That ignorance, he warned, could be “manipulated into public hostility” toward embryo research. The conversation became frankly political, as several committee members voiced concern that the incoming Republican majority in the U.S. Congress would restrict funding for the research, including expected developments with human embryonic stem cells. The committee began to brainstorm ways to shape the policy and influence public reaction so that embryo research could receive government funding with minimum opposition. One committee member proposed a sophisticated strategy of political lobbying: “have us do our homework to determine which people in Congress ... have family members with which particular illnesses and make individual visits to them to ‘background’ them and brief them and discuss their particular family history concerns.” Scientists would respond to ethical objections against the destruction of nascent human life by entering the political arena; to make their case, they would rely not only on scientific facts but on emotionally charged appeals.
Fast-forward a dozen years. Embryo research became a hot-button political issue, and strikingly, just as had been anticipated in 1994, public officials and candidates for office regularly spoke about the issue in terms of their family health problems. So it was that, in considering legislation to fund embryonic stem cell research in April 2007, a series of Senators, one after another, described illnesses suffered by relatives, constituents, and themselves — a parade of maladies, from cancer to Parkinson’s to diabetes to asthma. One Senator, explaining his vote in favor of using taxpayer dollars to fund embryonic stem cell research, recounted his mother’s physical and mental decline due to Alzheimer’s disease: “When I look at her empty gaze and shriveled body, I cannot help but wonder, if we had started embryonic stem cell research years ago, would she still be suffering today?” While these Senators understandably focused on the face of the suffering that might be relieved if human embryos were destroyed for the sake of delivering a panoply of hoped-for cures, the imperative to relieve suffering was never in dispute, and they failed entirely to attend to the nature of the human embryo and its moral status — the ethical issue that was the very center of the debate.
These two remarkable snapshots — a government scientific advisory board strategizing about political lobbying, and politicians making passionate personal pleas about science policy — give us a glimpse of the strangeness of the debates about embryonic stem cell research from the 1990s through today. The stem cell debates have shown American politics at its best and its worst, with examples both of principled democratic discourse and plainly dishonest demagoguery. And stem cell research itself has shown us science at its most noble and its most debased, with examples both of brilliant researchers pursuing cures for terrible afflictions, and others committing egregious scientific fraud in the hunt for glory. As a result, the stem cell debates have helped to reveal the knotty and complicated relationship between science and politics.
This report examines the stem cell debates in hopes of better understanding the relationship between science and politics. It lays out for the public record the most important facts and arguments, some of which have been long neglected or distorted, so that we might better understand the purpose and limits of science in a self-governing society, the proper role of scientists in American political life, and how citizens and policymakers should think about both. This report examines when, how, and why the stem cell debates sometimes lapsed into error and exaggeration. It also reflects on the value of public deliberations about the fundamental questions of bioethics.
A comprehensive history of every aspect of the stem cell debates is beyond our present purposes, although the five appendices following the body of this report, each of which can be read as a standalone chapter, offer up-to-date explanations of the science of stem cells, the medical promise of stem cells, the ethical questions raised by stem cell research, the relevant policy and legal history, and other nations’ stem cell research policies.From Discovery to Debates
Stem cells are cells that have the ability to differentiate into one or more of the types of cells of an organism’s body, as well as the ability to self-renew, creating more stem cells like themselves. “Adult” stem cells — which are found not only in adults but also in children, babies, and fetuses — are typically multipotent, meaning that they are capable of producing multiple (but not all) cell types. Some adult stem cells have been used in medical therapies for decades. For example, bone marrow transplantation has been used to treat patients since the 1950s, years before scientists understood that it was specifically the presence of blood-forming adult stem cells in the marrow that made the treatment work.
Unlike adult stem cells, embryonic stem (ES) cells are pluripotent, meaning that they are each theoretically capable of producing all of the cell types of the mature organism. Human ES cells were first successfully derived in 1998 by cell biologist James A. Thomson of the University of Wisconsin. Thomson used embryos that had been created through in vitro fertilization (IVF) but had not been used for the purpose for which they were created: being implanted in a womb so that a woman or couple undergoing fertility treatment could have a baby. There are hundreds of thousands of such unimplanted human embryos stored in freezers at IVF clinics across the United States and around the world. (The science of stem cells is explained more fully in Appendix A.)
Thomson’s derivation of human embryonic stem cells was a long-anticipated breakthrough. Based on studies with mice, biologists had years earlier recognized the potential value to science of human ES cells. Their potential to develop into any type of cell in the human body was expected to give researchers a powerful new tool for studying human development. But it was their hoped-for application in the new field of regenerative medicine — using ES cells to replace a patient’s damaged or dying tissues — that captured the imagination of the public in the most dramatic way, as this ability could in theory allow doctors to reverse a myriad of degenerative conditions, from Parkinson’s to diabetes to spinal cord injuries. Stem cells, and especially embryonic stem cells, it was believed, would help usher in a new era in medicine. (The medical promise of stem cell research is discussed in Appendix B.)
However, ES cell research has stirred persistent ethical concerns, as obtaining human ES cells typically requires destroying human embryos. Thus, ES cell research demands that we consider the moral status of the human embryo. Many proponents of ES cell research consider the human embryo to be merely a “clump of cells,” morally no different from any other bit of tissue. By contrast, many critics of ES cell research argue that the human embryo is a human being at a very early stage of development, and therefore possesses at least the right not to be killed for research or to be exploited as a medical resource. Moreover, soon after human ES cells were first derived, scientists proposed employing the same technique that had been recently used to clone Dolly the sheep to create cloned human embryos for producing patient-specific stem cells for treatments, raising public concern over the ethics of human cloning. These and other ethical dilemmas divided the public over the hope of regenerative medicine and concerns for nascent human life. (The ethical questions raised by stem cell research are explored more thoroughly in Appendix C.)
Following Thomson’s discovery, stem cell research quickly became a contentious issue in American politics. The chief policy question was not whether such research should be made illegal, but whether human embryonic stem cell research should receive government funding — especially from the federal government, which is the largest source of funding for scientific and medical research in the country. On August 9, 2001, President George W. Bush announced a policy that would allow federal funding of the controversial research to proceed, but only for ES cell lines that had already been created, “where the life or death decision [had] already been made.” This policy would allow the government (and by extension, the American people) to support this promising area of medical research without encouraging future destruction of human embryos. The Bush funding policy became the subject of intense political conflict over the course of his presidency. It was eventually overturned by the Obama administration, which in 2009 put in place a new policy that encourages the destruction of some embryos — those produced for but not used in IVF procedures — in order to create new ES cell lines. The Obama funding policy has been challenged in a lawsuit that is currently wending its way through the federal courts. (The policy and legal history of ES cell research is laid out in Appendix D.)
Scientists, policymakers, political candidates, patient-advocacy groups, religious organizations, and other members of the public became embroiled in the debates over stem cell research. American scientists politically mobilized — as they rarely had before — in opposition to President Bush’s funding policy. Stem cell research became a prominent issue in the 2004 presidential race. There were various congressional attempts to overturn President Bush’s policy, and numerous initiatives at the state level, including a high-profile California referendum on funding for ES cell research. These heated debates raised important questions about the relationship between science and democracy and about how democratic politics should regulate ethically controversial research. By revisiting these debates, we address not only the particular questions regarding the ethics of embryonic stem cell research, but also questions of the place of science in the American polity.Science, Policy, and Politics
Before focusing on the interplay of science and politics in the stem cell debates, it is useful to step back and consider how they relate in general. Broadly speaking, we can distinguish between two ways science and politics relate to one another in the United States. First, government funds, regulates, organizes, directs, endorses, and prohibits different aspects of the scientific enterprise. Second, science provides policymakers with information and advice regarding natural phenomena, technology, and other matters relevant to public policy. These different relationships between science and policy correspond to two distinct senses in which we use the term “science.” When we speak of science policy as the way government supports or limits science, we are speaking of science as a project or practice, carried out by members of our society and subject to democratic political authority like any other activity. When we speak of the way government seeks science or scientific advice, we speak of science as a kind of knowledge concerning the natural world, knowledge that is subject to critical analysis and debate but not to political authority or regulation.
Although the policy questions in the stem cell debates chiefly concerned the first sort of relationship between science and politics, namely how the government ought to support or regulate this medically promising but ethically controversial field, the second sort of relationship has also been integral to the stem cell debates: scientific knowledge concerning the nature of the human embryo has been essential in informing policymakers and the public in their moral reasoning on the topic.
Historically, the federal government has provided considerable support for the scientific project. The classic articulation of postwar science policy in the United States is found in Vannevar Bush’s 1945 report to President Franklin Roosevelt, Science, The Endless Frontier. In this influential report, Bush (no relation to President Bush) argued that government funding for science, particularly for what he dubbed “basic research,” was essential to ensuring that America continue to enjoy the technological progress necessary for the nation’s strength and prosperity. Vannevar Bush’s model of scientific progress held that basic research leads to applied research which leads to the development of useful technologies and products. Following this model, the U.S. government has since the end of the Second World War provided considerable funding for scientific and medical research, with consistent public approval.
During the latter half of the twentieth century, the U.S. government also came to recognize the importance of regulating scientific research, particularly biomedical and behavioral research conducted on human subjects. The horrific scientific experiments performed by Nazi doctors during the Second World War, along with other cruel and unethical experiments performed in the United States and around the world, clearly demonstrated the need for ethical oversight of scientific research. Governments around the world instituted policies on research ethics and the protection of human subjects, based on the principles articulated in such documents as the Nuremberg Code and the Belmont Report.
Meanwhile, science, understood as our most reliable source of knowledge about the natural world, rightly enjoys a great measure of authority. In our political life, we rely on science to settle questions regarding purely physical phenomena: the toxicity of different chemicals, the efficacy of medical treatments, the sturdiness of bridges, the effects of pollution, and so on. In crafting policy, we weigh these scientific facts against other facts, interests, and values. Scientific knowledge can also inform our moral reasoning. A scientifically accurate description of biological death, for instance, is critical for determining the ethics of organ donation, and for developing sound policies to regulate organ donation.The Bush Funding Policy: How Science Informed Ethics and Politics
Crafting morally sound policies for stem cell research requires at least three kinds of scientific knowledge: first, an account of the medical treatments that stem cell research might make possible — along with an account of the likely challenges facing this research — so that we might judge whether funding such research is in the public interest; second, an understanding of biology and specifically embryology, so that we can reason about the moral status of the human embryo; and third, an assessment of the methodology and viability of alternative sources of stem cells for research and therapy so we can consider alternative policies.
In developing his administration’s stem cell funding policy, President Bush sought out scientific advice on precisely these questions. These scientific matters were also central to the deliberations on stem cell research conducted by the President’s Council on Bioethics that he established. President Bush was aware of the potential benefits of stem cell research; he and his staff consulted a wide range of scientific and medical experts in formulating his 2001 policy, and in his speech unveiling the policy, he spoke of the “great promise” of the research to “help improve the lives of those who suffer from many terrible diseases — from juvenile diabetes to Alzheimer’s, from Parkinson’s to spinal cord injuries.” He also alluded to scientific facts about the developing embryo: “Like a snowflake,” Mr. Bush said, “each of these embryos is unique, with the unique genetic potential of an individual human being.”
As the science evolved in the wake of President Bush’s 2001 decision, it seemed increasingly likely that new alternative techniques would make possible the creation of pluripotent stem cells without the destruction of human embryos. President Bush adjusted his administration’s policy accordingly, directing the NIH in 2007 to vigorously pursue these alternatives.
Once again, scientific knowledge was crucial not only to evaluating the technical feasibility of these alternative sources for pluripotent stem cells, but also in informing the ethical judgments about the proposed alternatives. Most of the alternative sources of stem cells involve complex technical procedures, and deciding whether a particular alternative is ethically acceptable can hinge on complicated scientific questions. Recent advances in the fields of embryology, developmental biology, and epigenetics have helped scientists to better understand early human embryonic life, making it possible to distinguish between living embryos and the component parts of embryos that it would be less ethically objectionable to use for research. (The most prominent alternative stem cell techniques are discussed in detail in Appendices A and C.)Ten Common Misrepresentations
The debates over stem cell research have dealt with a wide range of topics and issues, from cutting-edge science to deeply held moral values to arcane aspects of policy and law. In part due to the complexity of the subject, and in part due to the passionate intensity inspired by the concerns and interests on both sides, many misrepresentations, misunderstandings, and sometimes even willful deceptions became part of the debate. Public officials who may not have understood the relevant facts sometimes made misinformed and misleading claims regarding the science, while scientists sometimes misrepresented the intentions and effects of public policy. The ethical stakes in the debate were hotly contested and were subject to both accidental and knowing misinterpretation. Even academic bioethicists, who would seem to bear a professional responsibility to understand and clearly communicate the complexities of these issues to policymakers, scientists, and the general public, often twisted the facts.
We present here ten of the misrepresentations most frequently heard during the stem cell debates. In doing so, we aim to clarify the public record and to correct some common, but important, errors that have made an already vexed controversy even more difficult. Furthermore, by better understanding the origins of these misrepresentations — when and why policymakers, scientists, bioethicists, and the public went wrong — we can better understand the relationship between science and politics.
Misrepresentation 1: The Bush administration banned stem cell research. The chief policy question concerning human ES cell research in the United States has not been its legality. Although there have been proposals to outlaw human cloning that would have impacted the ability of researchers to produce embryos for research purposes, these measures were not passed, and there have been no serious federal proposals for a general prohibition on research destroying human embryos. Instead, the central policy question at the national level has been whether and how such research will receive taxpayer funding. The Bush policy on embryonic stem cell research — like the Dickey-Wicker Amendment, a law passed by Congress every year since 1995 to regulate embryo research (described in Appendix D) — only concerns the ability of the federal government to allocate research funding. Neither the Bush policy nor the Dickey-Wicker Amendment outlaws any kind of scientific research, nor do they pertain to the allocation of state or private funding. Indeed, in terms of the kinds of stem cell research that are legally permissible, the United States has always ranked among the most liberal countries in the world, even under the Bush policy. (Laws of other countries pertaining to human embryonic stem cell research are discussed in Appendix E.)
Nonetheless, over the past decade, the Bush policy on federal funding for embryonic stem cell research — which explicitly permits funding on cell lines derived before August 9, 2001 — was frequently characterized by the media and by opponents of the policy as a “ban on stem cell research.” During the 2004 presidential campaign, Senator John Kerry (D.-Mass.), then running for president against Mr. Bush, said the following in a prepared radio address: “Three years ago, the President enacted a far-reaching ban on stem cell research, shutting down some of the most promising work to prevent, treat and cure Alzheimer’s, Parkinson’s, diabetes, AIDS and so many other life-threatening diseases.” Senator Kerry used the word “ban” three more times during the course of the short speech — clearly a considered and deliberate word choice intended to muddy the public understanding of the Bush funding policy, and to play into a growing political narrative that President Bush and his party were “anti-science.”
To be sure, some critics of the Bush policy may have called it a “ban on stem cell research” as shorthand, as a simpler way of saying a “ban on federal funding of research on embryonic stem cell lines derived after August 9, 2001.” University of Pennsylvania bioethics professor Arthur L. Caplan argued in an editorial published during the 2004 campaign season that the two ways of speaking about the Bush policy were equivalent: “prohibiting the expenditure of federal funds on embryonic stem cell research after August 2001 is a ban.” He has continued to repeat this claim up to the present, writing in April 2011 that the policy was “nothing more than a ban dressed up as a compromise.”
But describing the Bush policy as a “ban” on stem cell research obscures the important fact that stem cell research, including embryonic stem cell research, actually received federal funding under the Bush policy. In fact, under the Bush policy the NIH provided $294 million for embryonic stem cell research. In fiscal year 2008 alone, the NIH distributed over $88 million in grants for more than 250 projects involving human embryonic stem cells.
Moreover, describing the Bush policy’s restriction on federal funding as a ban on research implies that the freedom to carry out research in the United States is tantamount to a right to receive federal funding for that research. Yet the U.S. government has always permitted many more activities than it funds, and it is not immediately clear why scientific research has more right to receive federal funding than any other socially valued activity in America. Research that involves practices that raise ethical concerns — such as the destruction of human embryos — may not enjoy a level of approbation among Americans that would justify support from the federal government.
Misrepresentation 2: Embryonic stem cells are superior to adult stem cells, or adult stem cells are superior to embryonic stem cells. One of the most common misrepresentations of stem cell science and therapy has been the idea that one kind of stem cell is definitively better than other kinds. Advocates of embryonic stem cell research have often emphasized and exaggerated the potential of ES cells without acknowledging the extent to which adult stem cells may be useful to research and therapy. Meanwhile, some opponents of embryonic stem cell research have claimed that adult stem cells are definitively better than embryonic stem cells for providing therapies.
The pluripotency of ES cells makes them potentially a much more powerful medical resource than adult stem cells, which have more a limited developmental capacity. It may be possible to use pluripotent stem cells to create nearly any kind of cells for researchers to work with in modeling diseases and testing treatments at a cellular level. And since they can make nearly any kind of cell in the body, they have long been anticipated as uniquely valuable for regenerative medicine (although the threat of transplant rejection and the risk of tumorigenicity pose significant hurdles to the successful translation of stem cell research to clinically useful medicine). Work with adult stem cells, meanwhile, faces a number of difficulties, including the problem of isolating, purifying, and cultivating them in vitro; and their limited potency, along with the difficulty of finding adult stem cells for every tissue type, make it particularly difficult for researchers to use adult stem cells to create tissue types for a wide variety of conditions. Researchers therefore have good reason to suppose that ES cells could be a more effective tool than adult stem cells for understanding and treating many diseases. While there are as yet no treatments in regular use that rely on human ES cells, a handful of clinical trials are now underway.
Adult stem cells, as mentioned above, have been used for years in treating patients. Some such treatments, such as the use of bone-marrow transplantation for blood diseases like leukemia, antedated the knowledge that it was specifically stem cells that made the treatment work. Even now, many of the most exciting medical advances using stem cells rely on adult stem cells, including the recent creation of an artificial trachea and the successful treatment of HIV using bone marrow transplantation. Experimental studies have found evidence for the effectiveness of adult stem cells in treating a number of diseases, but it is important to remember that most stem cell-based therapies are still in the early stages of development, and it is too soon to say whether or not adult stem cells will prove effective in treating complex degenerative conditions like Parkinson’s disease or spinal cord injuries. Likewise, it is too soon to say definitively whether embryonic stem cells will prove more effective than adult stem cells for treating these diseases. (For a more detailed analysis of the potential applications of adult and embryonic stem cells, see Appendices A and B.)
Critics of ES cell research generally object to it on ethical grounds, and so have an incentive to exaggerate the promise of adult stem cells, which do not raise the same ethical concerns. These critics have also unfairly downplayed the promise of ES cell research, belittling it as “wishful thinking and hype.”
Meanwhile, supporters of ES cell research have their own incentives to spin the science, including the desire to ensure that the research receives government funding. As a result, they have exaggerated the promise of ES cell research. Although there has been a perception among some opponents of ES cell research that advocates deliberately denigrated the value of adult stem cells, it would be more accurate to say that advocates simply focused most of their attention on the line of research they believed to be the greater prize and did not meet less morally problematic alternatives with the same level of interest, generally because they did not see embryonic stem cell research as morally problematic in the first place.
An illustration of the distortions and exaggerations on both sides can be found in an exchange of four letters published in Science in 2006 and 2007. First, in July 2006, three scientists who publicly supported human ES cell research — Shane Smith, William Neaves, and Steven Teitelbaum — wrote a letter to the journal condemning the work of David A. Prentice, a biologist affiliated with a conservative think tank, who opposes human ES cell research. Smith and his colleagues argued that Prentice had exaggerated the therapeutic applications of adult stem cells in a widely publicized list of 65 diseases (and counting) that Prentice claimed were treatable by adult stem cell therapies. Most of the treatments Prentice cited, Smith and his coauthors noted, “remain unproven and await clinical validation,” while others, such as those for Parkinson’s and spinal cord injury, were “simply untenable.” They called Prentice to task for the quality of his references, which included “various case reports, a meeting abstract, a newspaper article, and anecdotal testimony before a congressional committee,” along with publications that had “nothing to do with stem cell therapy.”
In January 2007, Science published a reply from Prentice (co-written with Gene Tarne, another critic of human ES cell research) in which he defended his work on the grounds that he had not claimed adult stem cell treatments were “generally available,” that they were “cures,” or that they were fully approved by the FDA, merely that adult stem cell treatments have provided “observable and measurable benefit to patients.” He complained that his critics had failed to acknowledge several of his more legitimate sources, and also argued that there were at the time over 1,200 clinical trials related to adult stem cells underway. However, Prentice also took the opportunity to go on the offensive, pointing out that backers of human ES cell research — including two of the authors who had criticized him in Science — supported groups that irresponsibly exaggerated the potential of ES cells by claiming that they could someday be used to treat or cure over 70 conditions, even though the evidence for that claim was shaky.
In June 2007, the journal published another letter from Smith and his colleagues critiquing Prentice’s work. This time they argued that the “enrollment of an experimental therapy in a clinical trial does not mean that it is an effective therapy.” They again criticized Prentice’s methods, noting that some of the 1,200-plus clinical trials he had found had nothing to do with adult stem cells. They further noted that, based on Prentice’s published claims, a major conservative organization was reporting on its website that patients “have access to adult stem cell therapy which currently provides safe and successful treatments for more than 70 diseases and injuries.... These are tangible therapies that are available today.”
Their letter was immediately followed in the same issue of Science by another reply from Prentice and Tarne. They argued that their central claim that adult stem cells have provided medical benefits for patients was unaffected by the points raised by their critics regarding the amount of evidence, and reemphasized their criticism of Neaves and Teitelbaum’s political involvement and the exaggerations of the value of embryonic stem cells. Each of the four letters ended with a stern rejoinder against “cruelly deceiv[ing] patients.”
Exaggerations and misrepresentations about the supposed superiority of embryonic or adult stem cells have waned in the last few years, partly because of the Obama administration’s decision to undo the Bush policy, and partly because of the arrival on the scene of promising new sources of pluripotent stem cells that do not require the destruction of human embryos. But the exaggerations and misrepresentations have not entirely abated. While everyone hopes that stem cell therapies — whether using adult, embryonic, or some alternative source of stem cells — will deliver on their promise to provide treatments for a long list of afflictions, it is important to temper that hope with critical analysis of the scientific evidence. Experts who mischaracterize the facts risk distorting the public debate and inappropriately raising — or dashing — the hopes of patients.
Misrepresentation 3: Somatic cell nuclear transfer is not cloning and does not produce embryos. As mentioned above, the technique used to create Dolly the cloned sheep has been advocated by some scientists as a way to procure embryonic stem cells with a known genome, either to study genetic diseases or to treat particular patients. The idea of cloning human embryos in order to destroy them for the sake of creating stem cells is disturbing to many Americans in its own right, but it also raises the specter, long envisioned in works of science fiction like the 1932 novel Brave New World, of using the same technique to produce cloned children.
The terms “reproductive cloning” and “therapeutic cloning” came into common parlance in the 1990s to distinguish between cloning intended to create a genetically identical organism and cloning intended to produce stem cells. The two terms denote the different ends to which cloning techniques might be applied, while making clear that the means in each case is cloning.
Some proponents of ES cell research responded to public concerns about cloning by engaging in terminological chicanery. They suggested that the technique used to create Dolly, somatic cell nuclear transfer (SCNT), should not be considered a kind of cloning unless it results in a viable pregnancy in the womb. This claim was most notably spelled out in a 2002 report from a National Research Council panel. The panel, chaired by Stanford University stem cell scientist Irving L. Weissman, argued that SCNT intended for reproduction and SCNT intended to create stem cell lines are “very different procedures” and that it is wrong to think of them both as kinds of cloning. The product of SCNT when intended for reproduction is a cloned embryo that will be implanted in a woman’s uterus, resulting in a newborn child. But, the panel argued, if SCNT is used to produce ES cells, the end product is the ES cells. Since the final step is “entirely different,” the panel argued, the two procedures should be considered distinct, and should be regulated differently. Weissman later explained that his panel was trying “to use neutral language ... devoid of emotion-bearing terms,” and so it opted to use the terms “reproductive cloning” and “nuclear transplantation to produce stem cells.” Many scientists, policymakers, and commentators have similarly insisted that SCNT is not cloning but is rather a technique that can be used for cloning.
Relatedly, some have argued that it is inappropriate to call the artifact created by SCNT an “embryo,” since that term connotes the earliest stage of a developing life, while the artifact might be destined for destruction so that its stem cells can be harvested. For example, Dr. Paul R. McHugh, a member of the President’s Council on Bioethics, proposed that instead of calling the product of SCNT an embryo, we should call it a “clonote” (parallel to the word “zygote,” which McHugh would restrict to the product of fertilization). Other commentators have suggested still other terms for this artifact.
In 2004, the leadership of the International Society for Stem Cell Research (ISSCR), an influential global organization of scientists formed in 2002, encouraged researchers to replace the term “cloning” with “nuclear transfer.” The ISSCR formed a “nomenclature task force” to deal with the public-perception problems posed by the term “therapeutic cloning,” and in September 2004 the organization released a position statement calling on researchers to abandon the term. The following year, biotech entrepreneur Paul Abrams lectured the ISSCR annual meeting about the need to junk the term “embryonic,” too: “If we adopt the view that an embryo means a cell is going to implant to make a baby, and none of what we’re doing is [making] cells to implant to make a baby, and we come up with different terminology, I think we will have more long-term political success.”
The problem with these forays into terminological revisionism is that the result of a successful SCNT attempt is always a cloned embryo, a living organism at its earliest stage, genetically identical (or nearly identical) to the organism whose somatic cells were used in the procedure. While human SCNT has not yet been successfully performed to create human embryos beyond a few cell divisions, evidence from animal studies indicates that the product of SCNT would have the developmental potential of a human embryo. The entity produced by a successful SCNT procedure, if taken out of the petri dish and placed in the womb, has the potential to grow to maturity. The claim that the intention to implant or destroy this entity determines whether or not it is an embryo is confusing at best and mendacious at worst. In either case, it is certainly not based on scientific facts.
This terminological dispute arrived in a California courtroom in 2004, in a legal episode flowing from Proposition 71 — a proposal that would commit the state to funding ES cell research at a large scale. Three leaders of the campaign for Proposition 71 sued to demand revisions to the state’s official voter pamphlet explaining the proposed law. The pamphlet included “pro and con” statements written by advocates for and against the proposition, with the “con” statement referring to “human cloning” and noting that “the perfection of embryo cloning technology ... will increase the likelihood human clones will be produced.” The lawsuit called those statements “false and misleading” since Proposition 71 and existing state law banned human cloning to produce children. The court had to decide whether or not it was false and misleading to describe SCNT as cloning.
To support their contention that SCNT is not cloning, the plaintiffs called as expert witnesses Weissman and another stem cell scientist, Evan Y. Snyder of the Burnham Institute for Medical Research. They argued that the SCNT procedure was not the same as cloning, because researchers would never intend to implant the “product” into a woman’s uterus, and therefore the process would never result in the creation of a human child. Weissman claimed that SCNT does not produce a “human embryo clone,” because the researchers destroy the blastocysts to extract ES cells, so the process “results in an embryonic stem cell line” rather than a cloned human embryo.
Among the expert witnesses for the respondents was cell biologist Stuart A. Newman of New York Medical College. Newman argued that a scientist’s intention to implant a cluster of liver cells in a uterus would not make them an embryo, and neither does an intention not to implant a blastocyst make it anything other than an embryo. Newman rebuked the supporters of Proposition 71 for claiming that “the material nature of a biological entity changes depending on the intention of the investigator,” calling it “an example of magical thinking, which is antithetical to modern science.” The judge agreed, siding with the respondents and allowing the voter pamphlet to continue to mention “human embryo cloning.”
It is interesting to note, as Newman pointed out in his testimony, that despite the effort to police the language used to describe human cloning, “cloning” remains a widely used term of art in the field of stem cell science. In fact, one of the scientific journals dedicated to SCNT-related studies — edited by no less a luminary than Ian Wilmut, the scientist best known for creating Dolly — was called Cloning and Stem Cells until as recently as 2010 (when it was renamed Cellular Reprogramming). The first apparently reliable report of human embryos created through SCNT, which was published in 2008, referred to “cloned human blastocysts” and “cloned human embryos.” So it is disingenuous to claim that the term cloning is simply inaccurate.
To be sure, the terms “reproductive cloning” and “therapeutic cloning” are imperfect in various ways, and several more precise terms have been proposed. For example, the President’s Council on Bioethics, in its first report, Human Cloning and Human Dignity (2002), used the terms “cloning-to-produce-children,” “cloning-for-biomedical-research,” and “cloned human embryo,” offering a thoughtful explanation for its choices. These terms convey not just the difference of the ends of SCNT but also the similarity of the means, and they indicate that the inherent nature and status of the entity created by SCNT is the same regardless of what researchers or doctors intend to use that entity for. Any terms intended to obscure these key facts — that SCNT is a cloning technique, and that SCNT produces an embryo that must be destroyed if researchers wish to obtain ES cells from it — distort the science and mislead the policy debate. Newman’s chastisement of his fellow scientists for indulging in “magical thinking” shows how advocates of ES cell research obfuscated ethically relevant scientific facts to protect the political interests of their research project.
Misrepresentation 4: As a result of the Bush funding policy, the United States fell behind other countries in stem cell research. Commentators, advocates, and policymakers opposed to President Bush’s funding policy frequently claimed over the last decade that the policy was causing the United States to fall behind other countries in stem cell research. In 2004, a group of over two hundred members of the House of Representatives signed a letter addressed to President Bush claiming that “leadership in this area of research has shifted to the United Kingdom.” In 2005 congressional debates, many Representatives offered variants of this claim, saying that the United States is “already falling behind the rest of the world,” “falling far behind other countries, like South Korea and Singapore,” “being left behind,” and so on. Senator Dianne Feinstein (D.-Cal.) said on the Senate floor in 2006 that Bush administration policies “have left our researchers far behind the rest of the world.... Evidence that the United States is no longer the world leader in embryonic stem cell research is mounting.... The United States ... remains at the starting line.” Senator Barack Obama, during his 2008 presidential campaign, claimed that the Bush policy had “handcuffed our scientists and hindered our ability to compete with other nations.”
Were these rhetorical contentions about the effects of the Bush funding policy supported by the facts? A paper by Jason Owen-Smith and Jennifer McCormick published in Nature Biotechnology in 2006 purported to show that the Bush policy had resulted in a “productivity gap” between American and foreign stem cell research that posed a “danger for U.S. biomedicine.” This analysis was widely publicized, with major news outlets repeating the authors’ judgment that U.S. stem cell researchers were “falling behind” their international counterparts.
In claiming to see a “productivity gap,” Owen-Smith and McCormick echoed Cold War-era talk of a “bomber gap” and “missile gap” between the United States and the Soviet Union — and just as those earlier “gaps” proved to be illusory, so too was the supposed gap in stem cell research. Notwithstanding the authors’ conclusions, the data they presented told a less drastic story, showing that the United States was in fact leading the field of human embryonic stem cell research: American scientists had published nearly half of the 132 articles reviewed by the study, with the remainder of the articles divided among authors from 17 other countries. Moreover, the number of stem cell papers authored by American scientists rose each year after the Bush policy was put in place. And 85 percent of all of the world’s published ES cell research during the years the authors studied used stem cell lines approved for funding under the Bush policy. The authors emphasized their finding that the proportion of studies authored by Americans declined, but that finding likely just indicated the growth of international science, in which the United States continued to provide the lead.
Two other analyses also released in 2006 confirmed that American scientists were out-publishing those from other nations. One, which counted the publications about human ES cells listed in the PubMed database between 1998 and 2005, found that 40 percent came from the United States, with the rest divided among 20 other countries. The nation with the next highest proportion was Israel, with just 13 percent. The other analysis surveyed the scientific literature regarding all kinds of stem cell research (not just human ES cell research), and found that the 13,663 articles about stem cells published by American researchers between 2000 and 2004 constituted 42 percent of the world’s total. German researchers were second, with just 10 percent of the total. (It is worth noting that Germany’s policy, which we describe in Appendix E, is more restrictive than the Bush policy.)
More recent analyses show that stem cell research flourished in the United States during the years that the Bush policy was in place, due to a combination of federal funding using the approved stem cell lines, state-funded initiatives, and private funding. In a survey of the human ES cell research literature over the past decade, New Scientist found that the United States has consistently dominated the field, with at least 40 percent of the world’s publications in every year since 2000. In the first half of 2011, 45 percent of the world’s scientific publications about human ES cells had at least one American author. It might be “tempting” to blame the Bush policy for making the United States fall behind in stem cell research, the magazine editorializes, but such blame would be “misplaced,” both because the country hasn’t fallen behind and because, to the extent that American researchers have proceeded slowly in bringing stem cell therapies to clinical trial, they have done so out of caution. “Again,” New Scientist editorializes, “don’t blame Bush.” (Of note, in the wake of President Obama’s lifting of the funding restrictions, some scientists are reportedly finding that intellectual property law in the United States poses a greater obstacle to their research than did the Bush policy.)
The argument that the Bush policy caused the United States to fall behind other countries in embryonic stem cell research also perpetuates a related misunderstanding, namely that the Bush policy was more onerous and restrictive than other nations’ policies. In reality, many European countries have policies that are equally or more restrictive than the Bush policy. Some have banned certain forms of stem cell research and related techniques, including SCNT, while the only federal policies in the United States that explicitly touch on stem cell research have related to the qualifications for receiving government funding. Many of the nations with restrictive policies on ES cell research have produced innovative and impressive work using adult and non-embryonic pluripotent stem cells; for instance, the recent creation of an artificial trachea using adult stem cells was a collaborative effort involving researchers from several European countries, including Italy and Germany, which have some of the world’s most restrictive stem cell policies. (Appendix E discusses the legal and regulatory status of stem cell and embryo research in several countries and international entities.)
Meanwhile, if the Bush policy made the United States fall behind the rest of the world, then it is hard to understand why the world’s first three clinical trials seeking to translate ES cell research into potential therapies have been taking place in the United States; why one of those clinical trials used ES cell lines approved for funding under the Bush policy; and why the first European clinical trial of a potential ES cell therapy, which was given the green light in 2011, is really only an extension of one of the three U.S. clinical trials, and is conducted by the same American company.
Finally, it is worthwhile to state openly and to scrutinize an unspoken premise of the claim that the United States is falling behind other countries in stem cell research. To speak of “falling behind” is to suggest that the United States is in a race with other countries. This suggestion is true in at least two senses: if American researchers make important discoveries in basic science, American scientific institutions will enjoy greater prestige and will attract better minds and more funding; similarly, if American researchers are the first to make marketable discoveries in applied science, American businesses will presumably profit before foreign businesses. In light of both of these hopes, the United States indeed has an interest in remaining competitive in international science. But it is surely not the only national interest, and to claim that the nation is falling behind in a given scientific field is not a decisive argument for rushing ahead in that field. The nation has moral responsibilities that must not be sacrificed on the altar of international competitiveness. The Bush policy sought to take those moral responsibilities seriously while allowing the science to progress — and, as we have seen, stem cell science has indeed continued to flourish in our country.
Misrepresentation 5: More than 100 million Americans with serious illnesses could be helped with treatments derived from stem cells. A claim often repeated over the last decade by proponents of stem cell research, especially human ES cell research, is that over 100 million Americans might potentially benefit from stem-cell derived treatments. The statistic was bandied about to indicate the miraculous potential of ES cells. It appears on hundreds of thousands of websites. It was featured in the 2004 Democratic Party’s national platform: “Stem cell therapy offers hope to more than 100 million Americans who have serious illnesses — from Alzheimer’s to heart disease to juvenile diabetes to Parkinson’s.” President Barack Obama cited the statistic during his 2008 campaign. The 100 million figure is ubiquitous, its source is almost never mentioned, and it is rarely challenged.
Of course, we have no way of knowing how many people might be helped with stem cell-derived treatments — the science is still far too young and uncertain for any informed estimates. What, then, is the source of this statistic? How could it be that 100 million Americans — one out of every three — is ailing and in need of stem cell therapy?
The figure apparently originates in a one-page opinion piece published in Science in February 2000. The author, the leader of a patient advocacy group, claimed that 128 million Americans would benefit from therapies derived from pluripotent stem cells (which at the time meant only embryonic stem cells). He reached this figure simply by adding up the number of Americans “affected by” cardiovascular diseases (58 million), autoimmune diseases (30 million), diabetes (16 million), osteoporosis (10 million), cancer (8.2 million), Alzheimer’s disease (4 million), Parkinson’s disease (1.5 million), severe burns (0.3 million), spinal cord injuries (0.25 million), and birth defects (150,000 per year).
The most charitable interpretation of the statistic is that one in three Americans might eventually suffer from a disease for which embryonic stem cells might possibly someday provide a treatment. But the statistic is usually cited in the present tense; note, for example, how the 2004 Democratic platform refers to Americans who have “serious illnesses.” The idea that one in three Americans currently suffers from conditions requiring cell therapy or regenerative medicine is comically alarmist. The Centers for Disease Control and Prevention reported that in 2009, 9.4 percent of Americans described themselves as having “fair or poor health.” Even if all of these unhealthy Americans wished to be treated with stem cell therapies, that would still only be one in ten Americans, or 30 million people. And even that scenario would depend on there being a stem cell-derived treatment for every condition affecting the health of Americans.
The methodology used to construct this figure is flawed, to put it mildly. It assumes that all of the patients with these ailments could be helped by stem cell-derived therapies. The notion that embryonic stem cells will provide “cures” for such broad categories of conditions as cardiovascular disease, cancer, and birth defects has only the most tenuous connection to actual stem cell science.
Misrepresentation 6: Therapies relying on stem cells are imminent. In addition to exaggerating the scope of therapeutic benefits from ES cell research, supporters of the research have exaggerated how soon such therapies would become available. There are specific examples of exaggerations from scientists, corporate spokesmen, and advocates. Some of these exaggerations may have been intended to attract funding; others may have been spoken out of ignorance about the science or about the long road from basic research to clinically effective treatment. Also contributing to the overall public sense of imminent cures was the constant press coverage — headlines day after day reporting on even minor scientific papers as though they were major breakthroughs, creating the misimpression that many stem cell-based cures were only a few years away. (This kind of exaggeration has not been confined to the United States: Robert Winston, a prominent British fertility scientist, said in a 2005 speech in his capacity as president of the British Association for the Advancement of Science that “During the political campaign to encourage the U.K. Parliament to accept liberal legislation [governing ES cell research], some parliamentarians were clearly led to believe that a major clinical application was just around the corner.”)
Policymakers also exaggerated the imminence of the research. For example, on October 11, 2004, Senator John Edwards (D.-N.C.), then a vice presidential candidate on the ticket with Senator Kerry, claimed, “If we can do the work that we can do in this country — the work we will do when John Kerry is president — people like Christopher Reeve are going to walk. Get up out of that wheelchair and walk again.” Reeve, who had died the day before, had been a quadriplegic since a 1995 horse-riding accident. The clear implication of Edwards’s comment is that a cure for paralysis was imminent, and that a particular political result was the necessary prerequisite of that cure. Even some supporters of ES cell research have criticized Edwards’s statement as a “canonical example” of “unjustified hype.”
Embryonic stem cell research faces considerable hurdles before we can expect to see successful therapies from it. As we describe in Appendices A and B, stem cell therapies of all kinds are extremely complex, difficult procedures that require detailed knowledge and expertise to perform successfully. Transplanting ES cells or their products raises the problem of immune rejection, and while many have argued that therapeutic cloning could provide patient-specific stem cells, scientists have had considerable difficulty creating human embryonic stem cells using this technique, not least because of the problems associated with procuring the vast number of human eggs necessary to perform the experiments. As of this writing, ES cell therapies have only reached the earliest stages of clinical trials, and many questions related to their safety and efficacy will need to be answered before they can ever become part of regular clinical practice.
Misrepresentation 7: A clear majority of Americans supports embryonic stem cell research. A number of polls over the past decade have indicated that a majority of Americans seems to support human ES cell research — and to the extent that congressional action is a proxy for public opinion, the repeated congressional attempts to repeal the Bush funding policy suggest that ES cell research has enjoyed relatively widespread political support. Critics of the Bush policy have pointed to these claims as an argument against the decision to withhold federal funds for research that most Americans wish their government to support.
However, polls that found high levels of support for embryonic stem cell research were often worded in ways that obscured the ethical issues concerning the research while highlighting the potential benefits. For example, a poll of registered U.S. voters by The Economist during the 2004 presidential election found that 65 percent of the respondents supported embryonic stem cell research. But the question was formulated so as to tell the respondents that the reason that some people oppose stem cell research is that “it uses cells from potentially viable human embryos,” while the reason some people favor the research was said to be that “the embryos otherwise would be discarded and that this research could lead to breakthroughs for treating serious diseases.” The respondents were not informed of the substantive ethical concern raised by the research, which is that the embryos are not just “used” but destroyed. Without this information, it is difficult for a voter who is unfamiliar with the techniques involved in embryonic stem cell research to see what is controversial about it.
Perhaps the most careful and probing attempt to understand public opinion about stem cells was a poll conducted in 2008 by the Ethics and Public Policy Center. That poll’s results revealed deep public ignorance about the facts of embryonic stem cell research and confusion about the moral questions the research raises. A third of the respondents believed, incorrectly, that ES cells had “actually resulted in a cure or treatment for any diseases.” The poll found that 69 percent of the respondents said they supported “stem cell research”; the number dropped to 52 percent when the question asked about embryonic stem cells specifically and explained that human embryos are destroyed. But when asked whether it is ethical or unethical to destroy human embryos, a majority (51 percent) said that it is unethical. And 62 percent of the respondents agreed with the following statement: “An embryo is a developing human life, therefore it should not be destroyed for scientific or research purposes.” The poll’s plainly contradictory findings show that the American public has less than a full and coherent understanding of the facts and the ethical questions of stem cell research. They also suggest a clear desire to pursue medical cures alongside a broad willingness to take into account moral challenges.
Even setting aside the empirical question of whether stem cell research is unambiguously popular, the premise of this misrepresentation is that majority opinion should act as the moral standard. Of course, in a democracy like ours, decisions are generally made according to the will of the majority. This is a fine guideline, but history is replete with examples where popular opinion proved disastrous as a moral compass. (Consider, for example, the popularity of segregation in 1950s Mississippi and Alabama.) Public figures have a duty not just to follow public opinion but also to lead it, especially on morally fraught questions — a duty, that is, to undertake the hard work of making rigorous arguments to convince minds, and expressing those arguments in a way that moves hearts.
Misrepresentation 8: Opposing embryonic stem cell research means opposing cures for suffering people. One of the tropes of the stem cell debates has been the claim that opposing ES cell research is the equivalent of opposing the potential practical, medical benefits of scientific research — as though the critics of the policy were opposed to cures. President Bush has been accused of “turn[ing] his back on the millions who stand to benefit” from ES cell research, of “putting narrow ideology ahead of saving lives,” and of telling sick people to “drop dead.” Opponents of ES cell research have been accused of being “against hope” — a formulation that has even made its way into political advertisements. They have also routinely been called “heartless.” The Internet is littered with blog posts and comments from people claiming that opponents of ES cell research want people to “suffer and die.”
Surely not all of those who level this sort of charge against the critics of stem cell research seriously believe it; in many cases, the accusation can probably be chalked up to rhetorical excess arising in the midst of heated policy debates and political contests. Ethical argument is replaced by indignation, which in turn gives way to defamation, as these advocates of ES cell research ultimately claim that opponents do not really care for human life.
The sad irony of this line of thought is that the core agreement among both advocates and critics of embryonic stem cell research is that we have a fundamental obligation to protect and care for human life. The core disagreement is over what sorts of beings constitute human life deserving our care and protection — more specifically, over what the status of a human embryo is, and whether it deserves the protection owed to a mature human being, or no protection at all, or something in between. This question is one on which reasonable, scientifically informed people can disagree. But all of the participants in the public stem cell debates wish to see disease cured by any ethically responsible means.
Misrepresentation 9: Opposition to embryonic stem cell research is a matter of religious ideology. It is true that much of the public opposition in the United States to human embryonic stem cell research has come from religious groups, particularly the Roman Catholic Church, but also from many evangelical groups and from Americans of other faiths. This fact has sometimes been invoked by supporters of ES cell research, with two apparent implications: that the critics of ES cell research hold their views for strictly religious reasons, and that therefore their views are illegitimate.
The notions that religious believers’ views on stem cell research are necessarily religious opinions, and that those views should be kept out of public debates, are mistaken and undemocratic. Let us deal with these errors in reverse order.
Citizens who have made moral judgments that have a bearing on public questions have a right to attempt to persuade their fellow citizens to enact policies informed by those moral judgments. The right to participate in the political process regardless of whether our moral and political judgments are rooted in religious or secular commitments is one of the fundamental tenets of democratic self-government. While the First Amendment prohibits the government from establishing a religion, it does not deny religiously informed moral and political argument a place in the public square.
Some might argue that because religious beliefs are based on faith and revelation, they are inherently private and not open to public analysis and debate — making them subversive to sound democratic deliberation. According to this argument, even if religious views are not strictly illegitimate in public, religion is a “conversation stopper” that harms fruitful public discussion of moral or political issues.
However, in the case of the debates over human embryonic stem cell research, religious believers who oppose the research do so on grounds that are publicly intelligible, and are at least as accessible to reasoned debate as are the grounds on which supporters of embryonic stem cell research endorse the destruction of embryos. Those who oppose the destruction of human embryos argue that they are a form of human life; that human life is valuable, has certain rights, and is owed our respect; and that we therefore should not deliberately destroy human embryos for our own purposes, however noble those purposes may be. Each of these claims may be controversial, and clearly there is widespread disagreement on the moral status of the human embryo, but the argument against destroying human embryos need not depend on any theological reasoning or inaccessible faith commitments. The belief that even early human embryos are a form of human life is a straightforward interpretation of the biological facts, and while some philosophers may dispute the claim that all human life is unconditionally valuable, it is a perfectly intelligible moral position. Indeed, it is one of the great ironies of the stem cell debates that the opponents of embryo-destroying research have tended to emphasize scientific, rational knowledge concerning the nature of the embryo, while the supporters of such research have tended to rely on emotional appeals to our desire for medical treatments, or to arguments that the “personhood” we value in human life only emerges at some later, typically unspecified stage of development.
Misrepresentation 10: The Bush stem cell funding policy was an illegitimate politicization of science. This has been a prominent claim by public commentators and advocates of embryonic stem cell research — most notably President Obama, who described ending the Bush policy as a step toward “ensuring ... that we make scientific decisions based on facts, not ideology.”
In point of fact, there are no participants in the stem cell debates who will deny, if pressed, that public policy must be based on both facts and moral considerations. For instance, in the very same remarks, President Obama noted that he would restrict federal funding for reproductive cloning because it is “profoundly wrong, and has no place in our society, or any society” — moral judgments that are not settled by scientific fact alone. Other aspects of science policy are obviously moral as well: for example, there is universal agreement today that scientific research on human subjects ought to be conducted with informed consent, a principle that arose in part out of the horror at the work of the Nazi doctors and the Tuskegee experiments. Yet, although informed consent is by definition a restriction on scientific autonomy, no credible person would dismiss it as an improper “ideological” imposition. The notion of a purely scientific decision is itself meaningless: it would be impossible, even if we wished to, to decide what we ought or ought not to do based on scientific facts alone, without relying upon principles of some sort. Even the value we place on scientific inquiry and knowledge is itself non-scientific — that is, we value science because we value knowledge and the practical goods that science can bring us; but scientific knowledge is itself neutral as to whether or not we should value it, or for that matter whether we should value the scientific project that provides us with this knowledge. Pretending that we can somehow denude science policy of moral judgment confuses the public understanding about the proper relationship between science, moral judgment, and public policy. It also threatens to erode the foundation for restricting even those forms of research that most people agree violate ethical principles.
As we reflect on the stem cell debates, there are three key points on which all participants should and generally do agree: (1) the advancement of scientific knowledge, as part of our broader search for knowledge and truth, is good for its own sake; (2) scientific research is of enormous value for the medical and practical benefits it has brought and may yet bring; and (3) society in general, and public funding in particular, ought to support scientific research to the greatest extent that is ethically (and fiscally) responsible. The central question in the debates has been, again, whether experimentation on embryonic stem cells obtained by destroying human embryos is ethical — a matter upon which reasonable, scientifically informed people can be expected to disagree. The claim that it is illegitimate for these ethical views to be expressed in public policy represents a profound misunderstanding of the proper relationship between science and politics. We say more about that relationship in this report’s conclusion.Case Studies from the Stem Cell Debates
The stem cell debates were carried out in scientific journals, bioethics magazines, and the popular press, in classrooms, conference halls, and political campaigns. In this section, we examine a handful of critical incidents and individuals from the stem cell debates, the better to understand the complicated relationship between science, ethics, and political practice.
Scientific Expertise and Policy — Counting the Stem Cell Lines. A key element of President Bush’s 2001 funding policy was the existence of established stem cell lines, the use of which Bush believed could be ethically justified on the grounds that the direct act of destroying the embryos had not been incentivized or rewarded by the government. But a considerable controversy developed over the number of stem cell lines that were available, with one critic describing the number of cell lines estimated by the administration as “one of the most flagrant purely scientific deceptions ever perpetrated by a U.S. president on an unsuspecting public.” Examining this controversy points to important questions not only about the particular facts at dispute in this controversy, but about how policymakers should act in light of evolving factual knowledge.
Research involving mouse ES cells, which were first derived in 1981, had almost entirely relied on just two lines of ES cells. Proponents of human ES cell research believed that only a handful of stem cell lines would be necessary for the work to progress significantly, with Stanford researcher Irving Weissman telling the New York Times that “a finite number [of ES cell lines] would be sufficient.... If we had ten to fifteen cell lines, no one would complain.”
At President Bush’s request, the National Institutes of Health in 2001 conducted a global survey of stem cell researchers; the agency reported back to the White House that roughly sixty stem cell lines had been established. That was the figure Bush cited in his address on August 9, 2001: “As a result of private research, more than sixty genetically diverse stem cell lines already exist.... Leading scientists tell me research on these sixty lines has great promise that could lead to breakthrough therapies and cures.”
However, many of the ES cell lines that had been created were either not viable or not available under intellectual property restrictions. The number of ES cell lines eligible for federal funding under the Bush policy dipped down to eleven and then rose to a final number of twenty-one.
Although the number of ES cell lines eligible for funding under the Bush policy was in keeping with what researchers like Dr. Weissman had hoped for, they grew dissatisfied. With respect to the eleven cell lines available in 2003, Weissman said, “you are only looking at the genetics of people who go to in vitro fertility clinics — the white, the rich, and the infertile.”
(Weissman’s comment, of course, reveals dissatisfaction with more than just the number of stem cell lines available; his criticism of the kind of embryos from which the cells were derived is tied to his longtime support of cloning for biomedical research, since cloning would make it possible to create stem cells that would be genetically identical to patients, allowing researchers to study genetic diseases at a cellular level. In 2002, Dr. Weissman launched a program at Stanford, among the stated aims of which is to clone human embryos for research purposes, and he continues to insist that the government should fund research on stem cell lines derived from cloned embryos.)
Although President Bush’s estimate of the number of established ES cell lines was based on the NIH survey, his political critics accused him of intentionally lying about the number — as part of a growing narrative that the president and his party were “anti-science.” Bush’s claim that there were sixty ES cell lines was “a morsel of scientific misinformation so stunning ... that one can only wonder what Bush and his handlers were thinking, or whether they were thinking at all,” wrote journalist Chris Mooney in his 2005 book The Republican War on Science.
Revisiting the scientists’ complaints about the number of lines approved under the Bush policy with the perspective of a few more years, it turns out that American researchers have overwhelmingly relied on just two of the twenty-one approved ES cell lines. Studies on a diversity of cell lines do have certain scientific advantages, but most researchers have preferred to work with the well-characterized H1 and H9 cell lines, which have a proven track record of productivity. Even after the new Obama funding policy went into effect, the Bush-approved lines remained by far the most widely used: a survey of the research presented at the 2010 International Society for Stem Cell Research conference found that over three-quarters of studies employed one or more of the cell lines approved under the Bush policy, and only 8 percent of studies used one of the cell lines newly approved under the Obama policy but not under the Bush policy. And while it is still too early to know what effects the Obama funding policy will have, a 2009 article in Nature Biotechnology pointed out that the Bush funding policy may have had the beneficial consequence of establishing “a reproducible yet small number of well-characterized lines [that] are now used as references for the community of stem cell researchers.”
One way to understand the controversy over the number of available stem cell lines is as a consequence of the differing aims of democratic government and technical expertise. Policymakers have a responsibility to seek out the best available expertise to inform their decisions. But experts disagree with one another, and their advice can rapidly shift with evolving knowledge. To accuse President Bush of “flagrant deception” for saying that sixty stem cell lines existed is to assume he acted in bad faith, when in truth our knowledge of the facts changed — just as the evolving factual landscape led scientists like Dr. Weissman to revise their views about the number of ES cell lines “sufficient” to advance the field. Moreover, and perhaps more importantly, these accusations of dishonesty ignore the broader issue that the Bush stem cell policy was primarily shaped not as a technical response to specific claims about a number of available stem cell lines, but as a considered effort to advance stem cell science within responsible ethical constraints.
Politics Distorting the Science — Ron Reagan and the Future of Medicine. During the 2004 political season, stem cell research became a major issue. Scientists organized and mobilized politically to a degree not seen since the 1964 presidential election; candidates for office gave speeches and purchased advertisements criticizing their opponents’ views on stem cell research; and the research became the focus of a major ballot initiative in California. We have already mentioned several misrepresentations that arose during the 2004 presidential campaign, including the repeated characterization of the Bush funding policy as a “ban” and Senator Edwards’s remarks about an imminent cure for paralysis.
The episode that epitomized the grossly misleading tactics employed in the stem cell debates occurred at the Democratic National Convention in July 2004. One convention speaker after another invoked the promise of stem cells and decried the supposed ban on research; the phrase “stem cell” was uttered twenty times, making it one of the policy topics most mentioned from the podium. Then, on July 27, just fifteen minutes after the keynote address by then-state senator Barack Obama, Ron Reagan, the son of the late President Ronald Reagan, rose to give a primetime speech advocating human embryonic stem cell research.
Reagan began by disavowing that he was delivering a political speech — although he was at a party convention, surrounded by throngs of cheering partisans, speaking on a subject that the Democratic Party had sought to use as a “wedge issue.” His talk certainly had all the trappings of a political speech, including policy recommendations and a stirring peroration promising voters that the Democratic ticket would ensure progress.
Given the attention Reagan’s speech enjoyed, with ample news coverage and a live television audience of millions, it is worth looking closely at the way his remarks irresponsibly distorted the scientific facts — both in what he said and what he did not.
First, Mr. Reagan wildly exaggerated both the promise and the imminence of treatments derived from ES cells. Although the science was still very young and unsettled, he claimed that ES cell-derived treatments for Parkinson’s disease would be available “ten or so years from now,” and described ES cell therapy as “what may be the greatest medical breakthrough in our or any lifetime” — apparently greater even than vaccination and antibiotics, which have saved hundreds of millions of lives.
Second, Reagan never explicitly stated that human ES cells are derived from human embryos that are destroyed in the process. Only attentive listeners already familiar with the science would have recognized that when Reagan spoke of “these cells” and “these undifferentiated cells multiplying in a tissue culture” he was referring not to the ES cells but to embryos themselves. In this way, Reagan avoided acknowledging that the embryo is a human organism — only conceding that “these cells could theoretically have the potential, under very different circumstances” to develop into recognizably human beings. Nor did he ever explain that creating ES cells requires the destruction of human embryos; he referred only to “interfering with the development” of embryos.
Third, he also eschewed the word “cloning,” even though he gave a two-sentence description of the SCNT therapeutic cloning procedure. The artifact resulting from that procedure is a cloned human embryo, a genetic near-duplicate of another human being. (Reagan also alluded to the cloning process by saying that ES cells are “created using the material of our own bodies” — a misleading turn of phrase that suggests that ES cells are, like adult stem cells, only made from our bodies and do not entail the destruction of distinct organisms.)
Virginia Kearney 13 days agofrom United States
Hi Selena. For a science journal, you need to record the date, the information you get from a source and the bibliographical information. Generally, I suggest that students write a short summary of the information they get from a source and then their response to that information, which can include what they learned, what questions the information made you think about, and what you thought was useful or important.
Selena Leong 2 weeks ago
This real helped me I was looking for topics for my research paper for days. Great thanks alot.
Any advice on how to write a science journal ?
Virginia Kearney 2 weeks agofrom United States
Hi Gloria, there are some life science samples in the topics above. Here are a couple more:
How is DNA analysis of ancient bones changing our concept of the evolutionary tree?
How is Biopharma changing healthcare?
Yolo 2 weeks ago
Thanks so much
Gloria T. Jauod. 2 weeks ago
I haven't tried doing science research but I want to try. I am interested on life science. Could you give me some samples?
Donald Trump 2 weeks ago
JEROME 3 weeks ago
Nkateko 5 weeks ago
Thanks for your idears they are so helpful
Virginia Kearney 7 weeks agofrom United States
That's a good idea explorer.
explorer1234 7 weeks ago
More topics related to space science would be great!
Valerie Chan 7 weeks ago
Interesting research on a great app for me to get a great time to share.
Angelyn 7 weeks ago
I love all the topics. All of it are interesting. Well, i need something for my research that the output will be tangible or can be use by others. Thanks for the help.
Alice 2 months ago
can you do a topic on drugs cigarettes and smoking?
Jerome Allen 2 months ago
This is a very great website
Virginia Kearney 2 months agofrom United States
Hi Bella--You need to look at my science fair article about growing flowers.
bella 2 months ago
hi love the articles but Im doing a lab that the title is: will a flower grow faster and more efficiently in cold or hot water but I don't know that purpose is? or the hypothesis.
katie eldeen 2 months ago
ok thankyou so much you have been very helpful I think I have a pretty good idea of what I'm going to do
Virginia Kearney 3 months agofrom United States
Hi Katie--I'd start with an example of when the physics of motion is helpful, or used, or happens in daily life. To decide which sort of motion to research, I'd go to some physics websites (or even Wikipedia) and look up the different kinds and see which one you find most interesting, or which one you think you could find the most information about. Sometimes, I suggest that before choosing a topic that students do some preliminary research, looking for information. If you can't find anything useful in 30 minutes or so, you should probably choose another topic.
katie eldeen 3 months ago
hi Virginia, I love your articles. I'm doing a 10-15 page research paper on physics of motion. this is a huge topic and I really need a good attention grabber. I have no idea what section of motion I'm going to be discussing, I also need some advice there. if you could help I would really appreciate it
email@example.com 3 months ago
I need this for my science and research class. I could see it's of great help.
Virginia Kearney 3 months agofrom United States
Hi Mega Sai, It would be a good idea for you to look at my other articles about how to write research papers and argument papers.
Mega Sai 3 months ago
hi ,i am so much intrested in doing research on an intresting topic thatsy i have selected the topic related to nano materials.can any one give an idea how to approach in the topic related to nanomaterials
Virginia Kearney 3 months agofrom United States
Hi Katie--You might want to look at my article on Technology topics because that has information about physical science topics. If you are working on Creationism, you might want to see my article about "Can Christians believe in Evolution?
katie eldeen 3 months ago
I need a cool topic about physical science, can you help?
Virginia Kearney 4 months agofrom United States
Good point, Jenna--I'll add a Chemistry section.
Virginia Kearney 4 months agofrom United States
Good point Jenna--I'll add a Chemistry section.
Virginia Kearney 4 months agofrom United States
Yes, Eli--astronomy is the study of the universe and that is part of science.
Virginia Kearney 5 months agofrom United States
Marley, you have a good idea about endangered animals. Here are some samples: How do we best save endangered animals? Or you can pick a specific one to talk about. How do we balance the interests of people and animals on our planet? Does buying up land and setting it aside as a nature refuge work to save endangered animals? Does Ecotourism help save endangered animals?
Marley 5 months ago
Maybe topics about endangered animals? Those are very interesting to me and other people.
Dameon 5 months ago
infectious diseases like the flesh eating disease is interesting to read about.
lauren 5 months ago
really interested in molecular biology and genome mapping
Virginia Kearney 5 months agofrom United States
Sure Samantha, although I don't know what information is available on that topic. You can search for "dog communication" in Google Scholar to get some idea of any studies that have already been done.
Samantha 5 months ago
we are doing a project for science and i want to do a project on how dogs communicate, would that be related to science?
lol 5 months ago
lol lol lol lol
mahnoor 5 months ago
please add some plant related topics
Anonymous 6 months ago
Interested in animals
maria 6 months ago
interested in moleculer biology and medicine
Ahmed 6 months ago
I am Interest in Data and communication network specially in performance analysis of VoIP over Wimax networks
Tshivhinda Murunwa 6 months ago
Thank you so much
Virginia Kearney 6 months agofrom United States
Hi Celeste--I have many different science fair project ideas with full instructions. Look at my profile for ideas.
Riley Bozarth 6 months ago
Plenty of cool topics in the Astronomy and Physics category
Celeste 6 months ago
I am at school and I wanna ask. What would be a good project for science research class? Were having difficulty picking a project for our 'science fair'. It isn't really a science fair though more like a presentation. What good ideas can I use with like space stuff?
Virginia Kearney 6 months agofrom United States
EunJae, you might want to look at my science experiment about the salinity of water in agriculture.
EunJae 6 months ago
How about in agricultural aspects? Are there any common problems that arising nowadays? I really need help. Thank you.
kabiru 6 months ago
it was interesting
Yusuf kurt 6 months ago
I'm really interested in theoretical physics
Virginia Kearney 7 months agofrom United States
Hi Lily, I have a lot of different science fair projects I have designed. The one that seems to suit your idea best is "How does salt water affect seed germination." It is on owlcation, and you can find it by searching my profile page or googling it, or this link: https://owlcation.com/stem/Science-Project-How-Doe...
Lily 7 months ago
Hi Virginia. I have a science fair coming up and I need help for a topic. So I've already put down environmental management as my topic and "destruction" as my heading because I was going to conduct an experiment on something else. But now that won't work and I'm planning on doing a research project. So do you have any ideas of what I could say that has anything to do with the destruction of the earth? It would help if you would reply ASAP. Thanks xxx
firstname.lastname@example.org 7 months ago
Thank you for this information and I am learning from you
Virginia Kearney 7 months agofrom United States
Hi Annie, you might try one of the following: Do multi media science presentations work more effectively to help students retain information? Which type of multi media teaching method is most effective for science students?
Annie Blase 7 months ago
hi! ..I would like to have a research on teaching science through multimedia,, any suggestions what would be a good topic? Thank you..
Virginia Kearney 8 months agofrom United States
Jessica--Good topic idea! Something like: What is the value of space exploration of other planets for humans?
Jessica Jones 8 months ago
I think something on how looking at other planets in the universe helps us learn more about our own would be a good topic
Virginia Kearney 8 months agofrom United States
Hi Suzie! You've come to the right place. I have over 100 articles on writing and other articles on doing science projects. You can see my articles under my profile or just search for a topic. You can also see other articles written by me linked on the side.
Suzie Sheep 8 months ago
Hello Mrs. I would like some more tips for my students in my class. They all need a project on something. Cheers.
Mini 8 months ago
Thank you so much ma'am